When aging switches on Alzheimer’s

Molecular and Cellular Mechanisms of Neuronal Plasticity in Normal Aging and Alzheimers Disease

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Understanding the New Keynesian Model When Monetary Policy Switches Regimes

This paper studies a New Keynesian model in which monetary policy may switch between regimes. We derive sufficient conditions for indeterminacy that are easy to implement and we show that the necessary and sufficient condition for determinacy, provided by Davig and Leeper, is necessary but not sufficient. More importantly, we use a two-regime model to show that indeterminacy in a passive regime...

Does Fungal Infection Cause Alzheimers?

When neurogenesis encounters aging and disease.

In this review, we consider the evidence that a reduction in neurogenesis underlies aging-related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD). The molecular and cellular alterations associated with impaired neurogenesis in the aging brain are discussed. Dysfunction of presenilin-1, misprocessing of amyloid precursor protein and toxic effects of hyperphosphor...

Aging: when the ubiquitin–proteasome machinery collapses

In mammalian cells, protein degradation is an essential and dynamic process that is crucial for survival, growth, differentiation and proliferation of cells. Tellingly, the majority of intracellular proteins are degraded via the ubiquitin–proteasome system (UPS). UPS-mediated protein degradation serves qualitative and quantitative roles within the cellular proteome. For instance, UPS specifical...